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A Phase I Randomized Double

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trial MD,A.Matthey,MD,G.Gutknecht,MD,B.Lema A Phase I Randomized Double#238;tre

2 27 Abstract 28 Objectives 29 Protection induced by acellular vaccines can be short,requiring novel immunisation strategies.Objectives of this 30 study were to evaluate safety and capacity of a recombinant pertussis toxin (PTgen)-coated Viaskin A Phase I Randomized Double31 epicutaneous patch to recall memory responses in healthy adults.32 Methods 33 This double-blind,placebo-controlled randomized trial (Phase I Veliparib with carboplatin and paclitaxel in BRCA-mutated BROCADE3 was a randomised,double-blind,placebo-controlled,phase 3 trial done at 147 hospitals in 36 countries.Eligible patients (aged 18 years) had deleterious germline BRCA1 or BRCA2 mutation-associated,histologically or cytologically confirmed advanced HER2-negative breast cancer,an Eastern Cooperative Oncology Group performance status of 02,and had received up to two previous Veliparib with carboplatin and paclitaxel in BRCA-mutated BROCADE3 was a randomised,double-blind,placebo-controlled,phase 3 trial done at 147 hospitals in 36 countries.Eligible patients (aged 18 years) had deleterious germline BRCA1 or BRCA2 mutation-associated,histologically or cytologically confirmed advanced HER2-negative breast cancer,an Eastern Cooperative Oncology Group performance status of 02,and had received up to two previous

Some results are removed in response to a notice of local law requirement.For more information,please see here.Previous123456NextVideos of A Phase I Randomized Double

Watch video on Microsoft News1:26Michigan COVID-19 vaccine trial underway1 month agoMicrosoft NewsWXYZ Detroit,MIWatch video on Vimeo6:02Randomised double blind phase III safety and efficacy trial of the proposed trastu2 viewsAug 24,2017VimeoecancerWatch video on Vimeo3:07FORCE FOR COVID-19 Elimination Cr A Phase I Randomized Double#233;ation Nereo Films3.2K views4 months agoVimeoATCG PartnersSee more videos of A Phase I Randomized DoubleRandomised trials Cancer Research UKMost phase 3 trials and some phase 2 trials are randomised.Often there is one group who have the standard treatment they would have if they werent in the trial.They are the control group. A double blind trial is a trial where neither the researchers nor the patients know what they are getting.The computer gives each patient a code number.Some results are removed in response to a notice of local law requirement.For more information,please see here.12345NextVideos of A Phase I Randomized Double Watch video on Microsoft News1:26Michigan COVID-19 vaccine trial underway1 month agoMicrosoft NewsWXYZ Detroit,MIWatch video on Vimeo6:02Randomised double blind phase III safety and efficacy trial of the proposed trastu2 viewsAug 24,2017VimeoecancerWatch video on Vimeo3:07FORCE FOR COVID-19 Elimination Cr A Phase I Randomized Double#233;ation Nereo Films3.2K views4 months agoVimeoATCG PartnersSee more videos of A Phase I Randomized DoubleA Phase II,Randomized,Double-Blind,Multicenter,Based A Phase II,Randomized,Double-Blind,Multicenter,Based on Standard Therapy,Placebo-Controlled Study of the Efficacy and Safety of Recombinant Human Neuregulin-1 in Patients With Chronic Heart Failure [S0735109710008041_mmc1.doc] Footnotes.Some results are removed in response to a notice of local law requirement.For more information,please see here.

Randomized Double-Blind Phase II Study of Regorafenib in

Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma J Clin Oncol.2019 Jun 1;37(16):1424-1431.doi 10.1200/JCO.18.02374.Epub 2019Randomized Double-Blind Phase II Study of Maintenance Apr 09,2020 A Phase I Randomized Double#0183;Randomized Double-Blind Phase II Study of Maintenance Pembrolizumab Versus Placebo After First-Line Chemotherapy in Patients With Metastatic Urothelial Cancer Matthew D.Galsky,MD 1.x.Matthew D.Galsky.Search for articles by this author ;Randomized Double-Blind Phase II Study of Maintenance Apr 09,2020 A Phase I Randomized Double#0183;Randomized Double-Blind Phase II Study of Maintenance Pembrolizumab Versus Placebo After First-Line Chemotherapy in Patients With Metastatic Urothelial Cancer Matthew D.Galsky,MD 1.x.Matthew D.Galsky.Search for articles by this author ;

Randomised trials Cancer Research UK

Most phase 3 trials and some phase 2 trials are randomised.Often there is one group who have the standard treatment they would have if they werent in the trial.They are the control group. A double blind trial is a trial where neither the researchers nor the patients know what they are getting.The computer gives each patient a code number.Phase IIb,Randomized,Double-Blind Trial of GC4419This randomized,double-blind,placebo-controlled phase IIb trial was sponsored and financially supported by Galera Therapeutics.The protocol was approved by each institutions institutional review board and was registered at ClinicalTrials.gov identifier NCT02508389).Investigators obtained written informed consent from each participant.Phase I,Randomized,DoubleBlind,PlaceboControlled Jul 29,2013 A Phase I Randomized Double#0183;This 2part,phase I,randomized,doubleblind,placebocontrolled study evaluated the safety and pharmacokinetics of multiple intravenous infusions of sirukumab in 3 ascending dose levels in 31 CLE patients and in a single dose level in 15 SLE patients.In general,patients in this study had mild,stable,active disease.

Phase I,Randomized,Double-Blind,Placebo-Controlled

This was a phase I,2-part,international,multicenter,randomized,double-blind,placebo-controlled study.In part A,CLE patients were randomly assigned to 1 of 3 cohorts receiving ascending doses of sirukumab (1,4,or 10 mg/kg) or placebo administered via intravenous infusion (at a volume of 20 ml over 15 minutes and 80 mg/minute)Phase I Randomized,Double-Blind Pilot Study of Micronized The study was a phase I,randomized (2:1),double-blind clinical trial.Six subjects were randomized to receive SRT501 and 3 placebo (titanium dioxide).Interventions were provided in clinical kits as a powder and reconstituted as described earlier.Patients ingested the formulation preoperatively daily for a minimum of 10 days and a maximum of Phase 3,randomized,doubleblind,placebocontrolled Aug 20,2020 A Phase I Randomized Double#0183;Researchers performed this multicenter,randomized,doubleblind,placebocontrolled,parallelgroup study to test the safety and effectiveness of teneligliptin,a highly selective dipeptidyl peptidase4 inhibitor,monotherapy compared with placebo in Chinese patients with type 2 diabetes mellitus inadequately controlled with diet and exercise.

Phase 3 Randomized,Double-blind,Placebo-controlled Multi

Apr 24,2020 A Phase I Randomized Double#0183;This is a Phase III,multicenter,double-blind,randomized,placebo-controlled study to assess the efficacy and safety of ruxolitinib in patients aged 12 years with COVID-19 associated cytokine storm.The study will enroll patients to ruxolitinib or placebo,in addition to standard of care (SoC) per local practice.Patterns of occurrence and implications of neratinib Study design.ExteNET is a double-blind,placebo-controlled,randomized phase III trial performed in community-based and academic centers in Europe,Asia,Australia,New Zealand,and North and South America (Clinicaltrials.gov identifier NCT00878709).The study design evolved through three global protocol amendments as described previously [].The final study design comprised three parts part Navafenterol (AZD8871) in patients with COPD aa randomized,double-blind,phase I study evaluating safety and pharmacodynamics of single doses of this novel,inhaled,long-acting,dual-pharmacology bronchodilator Dave Singh1*,Victor Balaguer2,Carol Astbury2,Ulrika W A Phase I Randomized Double#228;hlby-Hamr A Phase I Randomized Double#233;n3,Eulalia Jimenez4,Beatriz Seoane5,Cristina Villarroel6,Alejhandra Lei7,Ajay Aggarwal8 and Ioannis

Navafenterol (AZD8871) in patients with COPD a

Navafenterol (AZD8871) is a dual-pharmacology muscarinic antagonist 2agonist (MABA) molecule in development for the treatment of chronic obstructive pulmonary disease (COPD).The pharmacodynamics,safety and tolerability of single doses of navafenterol were investigated in patients with moderate to severe COPD.This was a randomized,five-way complete cross-over study.Methylphenidate Hydrochloride Modified-Release in Adults Dec 27,2013 A Phase I Randomized Double#0183;The study consisted of the following three treatment phases (Fig.1) (1) The double-blind dose-confirmation phase was a 9-week,double-blind,randomized,placebo-controlled,parallel-group period consisting of a 3-week titration stage and a 6-week fixed-dose stage to confirm the effective dose range of MPH-LA.Any therapies for ADHD,as well Immunogenicity and Safety of a SARS-CoV-2 Inactivated Jul 31,2020 A Phase I Randomized Double#0183;BACKGROUND The top priority for the control of COVID-19 pandemic currently is the development of a vaccine.A phase 2 trial conducted to further evaluate the immunogenicity and safety of a SARS-CoV-2 inactivated vaccine (CoronaVac).METHODS We conducted a randomized,double-blind,placebo-controlled trial to evaluate the optimal dose,immunogenicity and safety of the CoronaVac.

Clinical Trial Phases What Happens in Phase 0,I,II,III

Jun 21,2019 A Phase I Randomized Double#0183;Phase III of a clinical trial usually involves up to 3,000 participants who have the condition that the new medication is meant to treat.Trials in this phase can last for several years.Cited by 78Publish Year 2013Author Jacek C.Szepietowski,Surasak Nilganuwong,Anna Wozniacka,Annegret Kuhn,Filippa Nyberg,Ronald F.A phase III,randomized,double-blind,multicenter study Aug 01,2020 A Phase I Randomized Double#0183;This phase III,randomized,double-blind,multicenter,equivalence study (ClinicalTrials.gov identifier,NCT02754882; EudraCT,2015-004026-34) was conducted at 100 sites in 13 countries.All patients provided written consent,and trial conduct complied withCited by 54Publish Year 2015Author Won Park,Sang Joon Lee,Jihye Yun,Dae Hyun YooA Phase II,Randomized,Double-Blind,Multicenter,Based May 04,2010 A Phase I Randomized Double#0183;A Phase II,Randomized,Double-Blind,Multicenter,Based on Standard Therapy,Placebo-Controlled Study of the Efficacy and Safety of Recombinant Human Neuregulin-1 in Patients With Chronic Heart Failure [S0735109710008041_mmc1.doc] Footnotes.

Cited by 21Publish Year 2019Author Lara E.Davis,Vanessa Bolejack,Christopher W.Ryan,Kristen N.Ganjoo,Elizabeth T.Loggers,Sant PubMed

Comparison of the Pharmacokinetics and Safety of Three Formulations of Infliximab (CT-P13,EU-approved Reference Infliximab and the US-licensed Reference Infliximab) in Healthy Subjects A Randomized,Double-Blind,Three-Arm,Parallel-Group,Single-Dose,Phase I StudyCited by 186Publish Year 2010Author Runlin Gao,Jian Zhang,Liuquan Cheng,Xuesi Wu,Wei Dong,Xinchun Yang,Tianchang Li,Xifu Liu,YabPhase I,randomized,double-blind,placebo-controlled Phase I,randomized,double-blind,placebo-controlled,multiple intravenous,dose-ascending study of sirukumab in cutaneous or systemic lupus erythematosus.Szepietowski JC(1),Nilganuwong S,Wozniacka A,Kuhn A,Nyberg F,van Vollenhoven RF,Bengtsson AA,Reich A,de Vries DE,van Hartingsveldt B,Robinson DW Jr,Gordon R,Hsu B.Cariprazine Treatment of Bipolar Depression A Randomized Participants with treatment-emergent significant changes in lipid and glucose levels during the double-blind treatment phase in a randomized controlled trial of cariprazine for bipolar depression (safety population) a.Placebo (N=158) Cariprazine 1.5 mg (N=157) Cariprazine 3.0 mg (N=165) Clinical Laboratory Parameter

BioMarin Announces The Lancet Publishes Detailed

The global Phase 3 study was a randomized,double-blind,placebo-controlled study of vosoritide in 121 children with achondroplasia aged 5 to 14 for 52 weeks.(The enrollment age criteria were 5 Author Martin Reck,Alexander Luft,Igor Bondarenko,Serhii Shevnia,Dmytro Trukhin,Nadezhda V.Kovalenko,Publish Year 2020A phase I randomized,double-blind,controlled trial of Nov 08,2011 A Phase I Randomized Double#0183;Methods.We conducted a phase I,multicenter,randomized,double-blind,placebo-controlled,multi-arm (10) parallel study involving healthy adults to evaluate the safety and immunogenicity of influenza A (H1N1) 2009 non-adjuvanted and adjuvanted candidate vaccines.A phase I randomized,double-blind,controlled trial of A Phase I Randomized Double#0183;A Phase I,Randomized,Double-Blind,Placebo-Controlled,Single Ascending Dose,Multiple Dose,and Food Effect Trial of the Safety,Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects.Lesley Taylor 1,

A Phase I,Randomized,Double-Blind,Placebo-Controlled

Oct 30,2018 A Phase I Randomized Double#0183;A Phase I,Randomized,Double-Blind,Placebo-Controlled,Single Ascending Dose,Multiple Dose,and Food Effect Trial of the Safety,Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects.Lesley Taylor 1,A Phase 3 Randomized Trial of Voxelotor in Sickle Cell In a multicenter,phase 3,double-blind,randomized,placebo-controlled trial,we compared the efficacy and safety of two dose levels of voxelotor (1500 mg and 900 mg,administered orally once A Phase 2a,Double-Blind,Placebo-Controlled Randomized Aug 20,2020 A Phase I Randomized Double#0183;To evaluate efficacy and safety of AZD1419,an inhaled TLR9 agonist,in a phase 2a,randomized,double-blind trial.Adult asthma patients with a history of elevated eosinophils ( A Phase I Randomized Doublegt;250 cells/L) were randomized 1:1 to receive 13 once-weekly doses of inhaled AZD1419 (1,4,or 8 mg; n=40) or placebo (n=41).

A Phase 1b/3 Global,Randomized,Double-blind,Placebo

Phase I.A Phase 1b/3 Global,Randomized,Double-blind,Placebo-Controlled Trial of Tazemetostat in Combination WithDoxorubicin as Frontline Therapy for Advanced EpithelioidSarcoma.The purpose of this study is to learn about the effects,safety,and proper dosage of

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